Ai Fairouz (How Heavy Are the Dumbbells You Lift?) plays Jolyne Cujoh in the series, also part of the cast are: Mutsumi Tamura (Digimon Adventure tri.) as Ermes Costello, Mariya Ise (Hunter x Hunter 2011) as Foo Fighters, Atsumi Tanezaki (Dragon Quest: The Adventure of Dai) as Emporio Alnino, Yuichiro Umehara (Goblin Slayer) as Weather Report, and Daisuke Namikawa (Fate/Zero, Engine Sentai Go-Onger) as Narciso Anasui. Daisuke Ono also returns to reprise his role as Jotaro Kujo.
David Production returns to animate the series with Kenichi Suzuki from Parts 1-3 returning as the chief director, and Part 4's Toshiyuki Kato as the director. Yasuko Kobayashi will once again handle series composition, Masanori Shino (Black Lagoon) as character designer, Part 5's Shun'ichi Ishimoto as Stand designer, Yoshikazu Iwanami also returns as sound director, and Parts 3-5's Yugo Kanno returns to compose the show's music.
JoJo's Bizarre Adventure: Stone Ocean is set to premiere on Netflix globally this December 1st with the first 12 episodes of the series available on said platform. The series will then make its Japanese TV premiere on January 8, 2022 on TOKYO MX at 12:30am JST, MBS at 2:55am JST, and on BS11 at 12:30am JST.