- Josh Keaton (Green Lantern: The Animated Series) as Shiro, the pilot of the Black Lion and the de facto leader of the group/mentor.
- Steven Yeun (The Walking Dead) as Keith, the pilot of the Red Lion and an ace pilot. He's mysterious and stand-offish, but ultimately a good friend.
- Jeremy Shada (Adventure Time) as Lance, the pilot of the Blue Lion. He's goofy, overconfident, and desperate for approval. What's more is that he has the worst pick-up lines.
- Bex Taylor-Klaus (Arrow) as Pidge, the pilot of the Green Lion. He's short, thoughtful, whipsmart, and tech-savvy. He also searches for answers about his missing family.
- Tyler Labine (Tucker and Dale vs. Evil) as Hunk, the pilot of the Yellow Lion. This large man has a heart of gold and a really hungry stomach. He is surprisingly, tech-savvy.
- Kimberly Brooks (Mass Effect) as Princess Allura, the last surviving member of the royal family of planet Arus. She's a fierce leader coping with tremendous loss... and sadly, the target of Lance's "affections".
- Rhys Darby (Flight of the Conchords) as Coran, the adviser of the royal family of Arus.
The series is set to premiere on June 10th on Netflix with its first 13 episodes.