- Kento Yamazaki (JoJo's Bizarre Adventure: Diamond is Unbreakable) or Ryunosuke Kamiki (Rurouni Kenshin) as Tanjiro Kamado
- Kanna Hashimoto (Gintama) as Nezuko Kamado
- GACKT (Kamen Rider Decade the Movie: All Riders vs. Dai Shocker) as Muzan Kibutsuji
- Sho Hirano (Hana Nochi Hare) as Zenitsu Agatsuma
- Ryo Yoshizawa (Kamen Rider Fourze, Gintama) as Inosuke Hashibira
- Takeru Satoh (Kamen Rider Den-O, Rurouni Kenshin) as Giyu Tomioka
- Satomi Ishihara (Shin Godzilla, Sadako 3D) as Shinobu Kocho
- Masaki Suda (Kamen Rider W, Mr. Hiiragi's Homeroom) as Sanemi Shinazugawa
- Masaharu Fukuyama (Ryomaden, Rurouni Kenshin) as Tanjuro Kamado
Take note, this is just the potential casting that's been circulating within the production team. It is not yet confirmed if these actors will play the roles.
Based on Koyoharu Gotoge's manga of the same name, the series follows Tanjiro Kamado, a young boy becomes a demon slayer after his family was attacked and slaughtered by a demon, with her younger sister Nezuko becoming a demon, but still show signs of human emotion and thought. Tanjiro's goal is to find the demon responsible for this and turn Nezuko back into a human.