- Koji Yamamoto (Shin Ultraman, Kingdom) as Killer T Cell
- Riisa Naka (Alice in Borderland) as NK Cell
- Wakana Matsumoto (Kamen Rider Den-O) as Macrophage
- Maika Pugh as Platelet
- Shota Sometani (live-action Parasyte films) as Helper T Cell
- Rihito Itagaki (Kamen Rider Zi-O) as Red Blood Cell
- Ryo Kato (Patalliro!) as Senior Red Blood Cell
- Seishiro Kato (Tenchijin) as Shin Takeda
- Kyoko Fukada (Kamikaze Girls) as Hepatocyte
- Ainosuke Kataoka (Kingdom 3) as Pneumonia Coccus
- Shinya Niiro (Kamen Rider Kiva) as Streptococcus pyogenes
- Maju Ozawa (Kamen Rider Agito: Project G4) as Staphylococcus aureus
- SEKAI NO OWARI's Fukase in an unannounced role
Based on Akane Shimizu's manga of the same name, the original work follows the everyday lives of the 60 trillion cells living inside your body and how they work together to keep your body healthy!
Directed by Hideki Takeuchi (live-action Nodame Cantabile, Thermae Romae), written by Yuichi Tokunaga (live-action Kaguya-sama: Love is War), and with action sequences directed by Takahito Ouchi (Rurouni Kenshin, Yu Yu Hakusho), Cells at Work! is set to premiere this December 13th in Japan.
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